The great grudge match of which they speak is the upcoming showdown between IBM's supercomputer Watson and two former Jeopardy champions. In their podcast  former two-time Jeopardy champion George and Jeopardy fan Joan ponder whether a computer, even a really, really fast one, can think in real time as nimbly as a human. What about natural language, slang, humor? And if it can, what does it mean for libraries when a machine can evaluate and answer a question as well as a human being (dare we say, a librarian)? Listen to the podcast, think fast and watch the show on Monday.
George and Joan aren't the only ones who have been intrigued by this contest. Here is a New York Times article  discussing it, and here is an Engadget article  that includes links to the practice rounds George and Joan mention in the podcast. And a discussion on Web4Lib  is also talking about it.
Who do you think will win?